Toward understanding the role of G-protein signaling

G-protein–coupled receptors (GPCRs) regulate many facets of homeostasis by sensing extracellular signaling molecules. To exert a plethora roles, GPCRs use divergent and intricate networks. better understand the role GPCR signaling, it is an important goal to identify contribution every signal transducer its effectors. Recent advances in methodologies have provided unprecedented opportunity characterize aspects including GPCR–G-protein coupling, selective activation specific pathways, physiological roles signaling. Taking advantage their versatile properties, several methods been used generate extensive data sets comparing through large set GPCRs. Here, we review recent progress dissect discuss future directions research on